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Counterimmunoelectrophoresis in the Detection of Antibodies to Schistosoma Japonicum^*

Counterimmunoelectrophoresis (CIE) was used to detect antibodies to Schistosoma japonicum soluble egg antigen in 118 sera from people living in a schistosomiasis endemic area in the Philippines. The sera were also tested for antibodies by the circumoval precipitin test (COPT); 53% were found positive by CIE and 48% positive by COPT. No significant differences were found between the tests (P = 0.18 by McNemar's test). Crossreactions with sera from patients with intestinal capillariasis and monkeys with experimental angiostrongyliasis were not found and no false reactions were detected with sera from "normal" controls. The CIE test as used in the present studies was found to be comparable to the COPT in sensitivity and specificity as related to cross-reactivity with sera from nematode infections such as intestinal capillariasis and angiostrongyliasis. Results are usually available quickly with nearly 70% of any reactions occurring within 1 h. The test should be of value in seroepidemiologic surveys in schistosomiasis-endemic areas.

Accepted for publication July 9, 1977.

^* This study was supported through funds provided by the Naval Medical Research and Development Command, Navy Department, for Work Unit MR-01.09.01-0144, and the Bureau of Research and Laboratories, Philippine Health Department.

The research described in this report involved animals maintained in animal care facilities fully accredited by the American Association for Accreditation of Laboratory Animal Care.

The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the Philippine Health Department.

Address reprint requests to: Publications Office, NAMRU-2, Box 14, APO San Francisco, California 96263, or 7-1 Kung Yuan Road, Taipei, Taiwan, Republic of China.