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Tissue Eosinophil Proliferation and Maturation in Schistosome-Infected Mice and Hamsters^*

Extramedullary eosinophilopoiesis is described as a regular pathological feature of murine and cricetine schistosome infections. Using the Dominici staining technique, colonies of developing eosinophils were commonly found in certain tissue sites of dense oviposition, particularly in the liver, and in associated lymphoreticular tissues. The relationship of these observations to the role of eosinophilic leukocytes in schistosomiasis is discussed.

Accepted for publication October 8, 1977.

^* Supported by grants from the U.S.-Japan Cooperative Medical Science Program, NIAID (R 22 AI-02631) and from the Edna McConnell Clark Foundation (275-0036). Mekong schistosome-infected mice and hamsters were provided by Dr. John Bruce, University of Lowell.