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Further Experience with Mebendazole in the Treatment of Symptomatic Trichuriasis in Children^*

Mebendazole (methyl-5-benzoylbenzimidazole-2-carbamate: Vermox), a broad spectrum anthelmintic, cured 22 (88%) children with symptomatic trichuriasis when given as a single 6-day course in a dosage of 100 mg twice daily. A further 3 (12%) were cured after a repeat 6-day course of therapy. Thus complete parasite eradication was achieved in all. The administration of an antidiarrheal agent, loperamide hydrochloride (Imodium), appeared to enhance the efficacy of mebendazole. Both drugs were well tolerated and completely free of any toxic effects.

Accepted for publication August 27, 1977.

^* Address reprint requests to: Professor J. N. Scragg, Department of Paediatrics and Child Health, University of Natal Medical School, P.O. Box 17039, CONGELLA 4013, Natal, South Africa.

This article has been cited by other articles:

				J. S. KEYSTONE and J. K. MURDOCH Drugs Five Years Later: Mebendazole Ann Intern Med, October 1, 1979; 91(4): 582 - 586. [Abstract] [PDF]