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Effect of Immunization on Migration of Schistosoma Mansoni through Lungs^*

P. Minard, D. A. Dean, W. E. Vannier AND K. D. Murrell

Schistosoma mansoni schistosomula migrate through the lungs of infected mice; peak recovery occurs 6 days following infection. When cercariae were irradiated at ⁶⁰Cobalt doses of 24 to 64 Kr, the number of schistosomula recovered from lungs 6 days after infection decreased in a dose-dependent fashion. The pattern of lung migration of schistosomes irradiated at 56 Kr prior to infection was similar to that of nonirradiated schistosomes, but greatly reduced numbers were recovered. When mice were immunized by a single infection with 56 Kr attenuated cercariae 6 wk prior to challenge, the pattern of challenge migration through the lungs was altered. The number of schistosomes recovered increased rapidly between 2 and 6 days post-infection, and showed a plateau between 8 and 10 days with peak recovery occurring 10 days post-infection. This peak recovery was reduced in comparison to that of nonimmunized mice, but did not account for all of the reduction observed at the adult worm stage.

Accepted for publication July 16, 1977.

^* Naval Medical Research and Development Command, Research Task No. MF51.524.009.0053, Office of Naval Research Contract No. N00014.76.C.0053, and a grant from the Edna McConnell Clark Foundation. The opinions or assertions contained herein are the private ones of the writers and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. The experiments reported herein were conducted according to the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Resources, National Research Council, DHEW Pub. No. (NIH) 74-23.

Current address: Box 14, Naval Medical Research Unit No. 2, APO San Francisco 96263.

Address reprint requests to: Dr. K. D. Murrell, Immunoparasitology Division, Naval Medical Research Institute, Bethesda, Maryland 20014.