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Am. J. Trop. Med. Hyg., 27(1), 1978, pp. 76-86
Copyright © 1978 by The American Society of Tropical Medicine and Hygiene

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Immunization of Mice with Cobalt-60 Irradiated Schistosoma Mansoni Cercariae*

P. Minard, D. A. Dean, R. H. Jacobson, W. E. Vannier AND K. D. Murrell{dagger}
Immunoparasitology Division, Clinical and Experimental Immunology Department, Naval Medical Research Institute, Bethesda, Maryland 20014

Parameters of immunization of mice with 60Cobalt-irradiated Schistosoma mansoni cercariae are described and related to protection against subsequent challenge infection. Such immunization was found to be dependent on dose of irradiation, number of immunizing cercariae, and number and time course of infections. Low levels of resistance were obtained with low irradiation doses, in contrast to previous studies in mice. In general, resistance increased with increasing irradiation doses, up to approximately 48–56 Kr. Maximal resistance (70–80%) was induced by a single exposure to 250–500 cercariae, irradiated at a dose rate of 2 Kr/minute to a total dose of 56 Kr, administered percutaneously 4–6 wk prior to challenge. Challenge could be delayed for at least 15 wk after immunization without a decrease in resistance. The resistance obtained was not attributable to a delayed migration of challenge worms.

Accepted for publication July 2, 1977.


* Naval Medical Research and Development Command, Research Task No. MF51.524.009.0053, Office of Naval Research Contract No. N00014.76.C.0053, and a grant from the Edna McConnell Clark Foundation. The opinions or assertions contained herein are the private ones of the writers and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large. The experiments reported herein were conducted according to the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Resources, National Research Council, DHEW Pub. No. (NIH) 74-23.


{dagger} Address reprint requests to: Dr. K. D. Murrell, Immunoparasitology Division, Naval Medical Research Institute, Bethesda, Maryland 20014.






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Copyright © 1978 by the American Society of Tropical Medicine and Hygiene.