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Plasmodium Falciparum: Responses of a Semi-Immune Individual to Homologous and Heterologous Challenges, and Non-Infectivity of Gametocytes in Anopheles Stephensi^*

Vincent C. McCarthy, David F. Clyde AND William E. Woodward

With strict adherence to ethical guidelines, a semi-immune volunteer was exposed to homologous and heterologous blood challenges with strains of Plasmodium falciparum from Vietnam and Tanzania. On both occasions infections developed, but clinical manifestations were moderated, prepatent periods increased, and parasitemias limited. Gametocytes produced by these infections failed to infect Anopheles stephensi. Possible reasons for this are discussed.

Accepted for publication June 4, 1977.

^* Supported by the U.S. Army Medical Research and Development Command under Contract No. DA-49-193-MD-2740. This is contribution No. 1461 in the Army Malaria Program.

Present address: Department of Tropical Medicine and Medical Parasitology, Louisiana State University Medical Center, 1542 Tulane Avenue, New Qrleans, Louisiana 70112.