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Immunity against Schistosoma Mansoni in the Mouse

The two experimental models now most widely used in the study of immunity to schistosomiasis are the mouse and rat. Each experimental host is endowed with its own set of advantages and drawbacks for this work. The model which we have chosen for our research on immunity to schistosomes is the inbred mouse. The principal advantage of this host is its full susceptibility to chronic schistosomiasis, a feature which has also made the mouse a prime model for the study of the pathology of disease. Ironically, the high susceptibility of the mouse to schistosome infection is also its major drawback as an immune model—for it is often difficult to dissociate the effects of protective immunity from those of the disease itself.

The murine model characterized by Dr. Smithers and myself at Mill Hill employed inbred mice (CBA or C57/BL) immunized by primary infection with small numbers of Schistosoma mansoni cercariae (25–35 each).