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Antieosinophil Serum

The lack of practical methods suitable for isolation and purification of individual cell types has precluded attempts to study granulocyte antigens and their specificity. While studies on the cell surface characteristics of the lymphocytes have identified two major classes and possibly subsets, investigations of granulocyte antigens are only just beginning. A leukocyte antigen that seems to be specific for the neutrophil has been described recently. In addition, sera from mothers of infants with neonatal neutropenia, or heterologous sera raised against neutrophils, demonstrated various specific immunologic effects. The cell surface membrane of the basophil has also been found to possess specific antigenic characteristics related to IgE. As we are beginning to formulate a clearer picture of granulocyte antigens, three subsets are now being recognized; 1) histocompatibility antigens that can be demonstrated on other cells as well; 2) cell-specific antigens that characterize each subset of granulocytes, namely, basophils, neutrophils, and eosinophils and also their precursors; 3) leukemia-associated antigens that are expressed along with the malignant transformation of granulocytes.