HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ottesen, E. A. Articles by Cheever, A. W. Search for Related Content PubMed PubMed Citation Articles by Ottesen, E. A. Articles by Cheever, A. W.

Immunoglobulin and Complement Receptors on Human Eosinophils and Their Role in Cellular Adherence to Schistosomules

Whatever the major functions of the eosinophil—whether related to cytotoxicity, modulation of inflammatory responses, or some other aspect of host defense—it is clear that intimate relationships must be established between this cell and its surroundings. These relationships necessarily involve the eosinophil's surface so that an understanding of its features, particularly those features termed its "membrane receptors," is essential for an appreciation of the range of this cell's functional potential.

A number of recent investigations have disclosed the presence of immunoglobulin and complement receptors on eosinophils; however, there has been considerable variation in the findings. In the present study we have undertaken first to define some of the important quantitative and biologic features of these receptors which might account for the differences reported from various laboratories and then to relate our findings directly to specific cell-parasite interactions using a schistosomule-leukocyte adherence assay. Eosinophils from normal individuals and from patients with helminthic infections were studied and compared.