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Mother-Child Relationship in Human Schistosomiasis Mansoni

I. Parasitic Antigens and Antibodies in Milk^*

Immunoglobulins, anti-Schistosoma mansoni antibodies, complement components and schistosome antigens were investigated in milk from mothers infected with S. mansoni. No significant differences of immunoglobulins or complement component levels were observed between infected and control mothers. Anti-S. mansoni antibodies were detected in the milk of 8 out of 25 infected mothers. A significant relationship was observed between serum and milk antibody levels. Two circulating S. mansoni antigens, parasite "M" antigen and antigen "4," were demonstrated in milk from infected patients by the double diffusion micromethod. The function of these immunologically active substances transmitted by milk from mother to child is discussed.

Accepted for publication March 26, 1977.

^* This work was supported by the "Centre National de la Recherche Scientifique" (C.N.R.S.—E.R.A. 422), the Institut National de la Santé et de la Recherche Medicale I.N.S.E.R.M.—A.T.P. "Bilharziose" 18-75-41) and the Brazilian "Conselho Nacional de Pesquisa" (C.N.Pq.).

Address reprint requests to: Ferrucio Santoro, Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, 20, Boulevard Louis XIV, 59012—Lille Cedex, France.