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Am. J. Trop. Med. Hyg., 26(6), 1977, pp. 1116-1128
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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Radical Cure of Infections with Plasmodium cynomolgi: a Function of Total 8-Aminoquinoline Dose*

L. H. Schmidt{dagger}, Rochelle Fradkin{ddagger}, Dennis Vaughan{dagger} AND Jane Rasco{dagger}
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35205, and The Christ Hospital Institute for Medical Research, Cincinnati, Ohio 45219

A series of studies on rhesus monkeys infected with sporozoites of the M and B strains of Plasmodium cynomolgi have shown: 1) at the same total course doses (with quinine as a companion blood schizonticidal drug) 7-day and 14-day dosage regimens of pamaquine, pentaquine, or isopentaquine are essentially equally effective in producing radical cure of infections with the M strain; 2) at the same total course dose (with chloroquine as a companion drug) a 7-day dosage regimen of primaquine is at least as effective as a 14-day dosage regimen in inducing radical cure of infections with the B strain, and may be slightly more effective; 3) at the same total course doses (with chloroquine as a companion drug), single dose, 3-day, and 7-day dosage regimens of primaquine or 4-methyl primaquine are essentially equally effective in producing radical cure of infections with the B strain. These observations have led to the conclusion that the total dose of 8-aminoquinoline administered is the primary determinant of radical curative activity, rather than the duration of drug treatment. This total dose concept derives support from currently available observations on the capacity of primaquine to cure naturally acquired and induced infections with P. vivax and underpins the current search for 8-aminoquinoline derivatives which will cure such infections when administered in single dose or three daily dose treatment regimens.

Accepted for publication April 2, 1977.


* The studies included in this report were supported in part by RG-47 (recoded E-8) from the National Institute of Health to The Christ Hospital Institute for Medical Research, Cincinnati, Ohio and in part by Contract DADA 17-69-C-9104 between Southern Research Institute and the U.S. Army Medical Research and Development Command. Manuscript preparation was supported in part by the above contract and in part by Southern Research Institute. This is contribution number 1459 from the Army Research Program on Malaria.

Address reprint requests to Dr. L. H. Schmidt, Kettering-Meyer Laboratory, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, Alabama 35205.


{dagger} Present address: Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama.


{ddagger} Present address: Children's Hospital Research Foundation, Cincinnati, Ohio.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.