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Hemostatic and Platelet Kinetic Studies in Dengue Hemorrhagic Fever^*

In an attempt to reveal certain aspects of the pathogenesis of the bleeding disorder in dengue hemorrhagic fever, hemostatic and platelet kinetic studies were carried out in 61 children with this disease. As has been shown by others, thrombocytopenia and hypofibrinogenemia were the two most prominent hemostatic defects constantly discovered. Increased intravascular clotting seemed to be one responsible factor, though not an outstanding one. This was evidenced by mildly and variably low factors II, V, VII, VIII, IX, X, and XII, and by mild to moderate increase of fibrin degradation products as well as low platelet counts and fibrinogen. In 11 cases platelet kinetic study revealed increased destruction as a main cause for the thrombocytopenia, most probably due to the underlying immunologic mechanism, i.e., via the immune complexes formed. Another factor was platelet dysfunction—the release of adenosine diphosphate.

Accepted for publication May 31, 1975.

^* Supported by research grant of Prince Songkla.

This article has been cited by other articles:

				S. Noisakran and G. C. Perng Alternate Hypothesis on the Pathogenesis of Dengue Hemorrhagic Fever (DHF)/Dengue Shock Syndrome (DSS) in Dengue Virus Infection Experimental Biology and Medicine, April 1, 2008; 233(4): 401 - 408. [Abstract] [Full Text] [PDF]