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Am. J. Trop. Med. Hyg., 26(5), 1977, pp. 963-969
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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Immune Response of Guinea Pigs to Schistosoma Mansoni

II. In Vitro Blastogenesis and Macrophage Migration Inhibition Factor Production in Responses to Cercarial, Adult Worm and Egg Antigens*

Priscilla Chen AND David A. Dean
Department of Oral Biology, State University of New York at Buffalo 14031, and Immunoparasitology Division, Naval Medical Research Institute, Bethesda, Maryland 20014

Guinea pigs infected with Schistosoma mansoni were tested for in vitro lymphocyte response to schistosome antigens and nonspecific mitogens at various times after infection. Production of macrophage migration inhibition factor by peritoneal exudate cells in response to cercarial, adult, and egg antigens reached a peak between 4 and 8 weeks post-infection and diminished rapidly thereafter. In contrast, peak blastogenic responses of blood lymphocytes appeared later than 8 weeks for all antigens and persisted until at least the 24th week. Blastogenic responses to concanavalin A and phytohemagglutinin P were not significantly different in normal and infected animals.

Accepted for publication February 1, 1977.


* Supported by the Naval Medical Research and Development Command, Work Unit Nos. MR011.-0001.02.0028 and MR041.05.01.0023A6GI. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large. The animals used in this study were handled in accordance with the provisions of Public Law 89-54 as amended by Public Law 91-579, the "Animal Welfare Act of 1970," and the principles outlined in the "Guide for the Care and Use of Laboratory Animals," U.S. Department of Health, Education, and Welfare publication no. (NIH) 73–23.

Address reprint requests to: Dr. David A. Dean, Immunoparasitology Division, Naval Medical Research Institute, Bethesda, Maryland 20014.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.