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Immunoglobulin E in Nigerian Onchocerciasis^*

Total serum IgE was measured by radioimmunoassay in 58 adult Nigerian patients with untreated onchocerciasis. Levels in excess of 244.9 IU/ml, the mean level of the healthy Nigerian control subjects tested, were found in 86% of the patients. The levels were comparable to IgE levels found in 15 atopic Nigerian patients from the same residential area (mean = 1,028.7 IU/ml). The findings suggest that onchocerciasis, like allergy, is one of the causes of elevated total serum IgE, though normal levels may occur in this disease.

Accepted for publication November 27, 1976.

^* This paper was part of a lecture given at the International Congress of Allergology, Buenos Aires, October 1976.

Address reprint requests to: Dr. A. O. Somorin, Allergy Clinic, Dermatology Unit, Department of Medicine, College of Medicine, University of Lagos, Private Mail Bag 12003, Lagos, Nigeria.