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Am. J. Trop. Med. Hyg., 26(5), 1977, pp. 1025-1027
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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The Binding of Chloroquine to Normal and Kwashiorkor Serum*

N. Buchanan AND L. A. van der Walt
Metabolic and Nutrition Research Unit, Baragwanath Hospital, and Department of Chemical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa

The binding of chloroquine to kwashiorkor and normal serum was investigated. The results show that more drug is bound in kwashiorkor serum, and that this occurs predominantly at the gamma globulin fraction. Therapeutically, in malnutrition there is no significant abnormality of protein binding with respect to chloroquine.

Accepted for publication February 26, 1977.


* Address reprint requests to: Dr. N. Buchanan, Metabolic Unit, Baragwanath Hospital, P.O. Bertsham 2013, South Africa.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.