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Hepatic Amebiasis: Diagnostic Counterimmunoelectrophoresis and Metronidazole (Flagyl) Therapy^*

In an ongoing study of obscure fevers in Cairo, Egypt which is presently in its 6th year, 12 cases of hepatic amebiasis have been diagnosed. Three were diagnosed during the period 1971–1974. With the introduction of amebic serologic techniques, particularly counterimmunoelectrophoresis, nine additional cases have been diagnosed in 1975–1976. Of 9 patients treated with metronidazole 6 were rapidly cured, 2 had a recurrence of fever necessitating surgical drainage of the abscess, and 1 died suddenly on the 3rd day of therapy.

Accepted for publication February 23, 1977.

^* Presented at the meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, 4 November 1976.

Supported by Naval Medical Research and Development Command NNMC, Bethesda, Maryland, Work Unit M0095.PN.12-5022, and Fevers of Undetermined Origin ONR Contract No. N00014.70.C-0193.

The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the Egyptian Ministry of Health.

Address reprint requests to: Tropical Medicine Department, NAMRU-3, FPO, New York 09527.