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Some Observations on Complement Fixation in Onchocerciasis in Guatemalans^*

Anne A. MacRae, Robert I. Anderson AND Louis E. Fazen

Recent investigations of infections with Onchocerca volvulus in Guatemala presented the opportunity to study some aspects of complement fixation (CF) antibody titers. An extract of adult O. volvulus obtained from nodules excised from patients was used as antigen. Serum was procured from individuals whose intensity of infection was determined by skin snip counts of microfilariae. In general there was an inverse relationship between intensity of infection and CF titers. This correlation was significant in men 40 years and older. The CF titer of women was greater than that of men with the same intensity of infection.

Accepted for publication December 14, 1976.

^* This study was funded in part by grants from the World Health Organization and the Robert Wood Johnson Foundation.

Address reprint requests to: Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205.

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