AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 26(4), 1977, pp. 597-601
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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Hemoglobin E and Glucose-6-Phosphate Deficiency in the Khmer Air Force (Cambodia)*

W. Douglas Everett, Akira Yoshida AND Elliot Pearlman
Department of Family Practice, USAF Medical Center, Wright-Patterson, Wright-Patterson AFB, Ohio 45433, Department of Biochemical Genetics, City of Hope National Medical Center, Duarte, California 91010, and SEATO Medical Research Laboratory, Rajavithi Road, Bangkok, Thailand

This study was designed to investigate the use of primaquine in malaria control in the Khmer Republic (Cambodia). Blood was drawn from 106 male Khmer Air Force troops for analysis of hemoglobin E and glucose-6-phosphate (G-6-PD) deficiency. A test group of 15 men with G-6-PD deficiency and a group of 31 normal controls were given 15 mg of primaquine each morning for 14 days. The patients were followed for hemoglobinuria and changes in hematocrit. Primaquine induced a significant, but not a dangerous, hemolysis in G-6-PD-deficient Khmer troops. The G-6-PD deficiency seen in Khmer Air Force subjects was G-6-PD Mahidol. Statistically, G-6-PD Mahidol was linked to hemoglobin E.

Accepted for publication January 10, 1977.


* This study was coordinated through Major General Khon Ken, the Khmer Surgeon General, and through Colonel Vatvani, the local Khmer Commandant.

The opinions expressed do not reflect the views of the Department of Defense, the United States Air Force, or the Air University.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.