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Am. J. Trop. Med. Hyg., 26(3), 1977, pp. 574-575
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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Chemotherapeutic Effects of a Nitrodiphenylaminoisothiocyanate (C9333-Go/CGP4540) on Jirds Infected with Brugia pahangi*

Howard J. Saz{dagger}, Gail A. Dunbar AND Ernest Bueding
Department of Biology, University of Notre Dame, Notre Dame, Indiana 46556, and Department of Pathobiology and Department of Experimental Therapeutics, The Johns Hopkins University, Baltimore, Maryland 21205

A small particle size formulation of 4-isothiocyanato-4'-nitrodiphenylamine has been found to have high chemotherapeutic activity when administered as a single dose to jirds infected with the filarial worm, Brugia pahangi.

Accepted for publication January 22, 1977.


* This investigation was supported in part by Grants AI-10512 and AI-09483 from the National Institutes of Health. Infected animals used in this study were provided by the U.S.-Japan Cooperative Medical Science Program-NIAID.


{dagger} To whom requests for reprints should be addressed.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.