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Am. J. Trop. Med. Hyg., 26(3), 1977, pp. 566-567
Copyright © 1977 by The American Society of Tropical Medicine and Hygiene

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Oral Infection of Mice with Trophozoites of Giardia muris

Ivo de Carneri* AND Franca Trane
University of Pavia, Milan, Italy, and Carlo Erba Research Institute, Via Imbonati, 24-20159 Milan, Italy

Giardia muris has been maintained for years in the mouse by administering by gavage 10,000 trophozoites taken from the small intestine of infected mice. Despite the growth of numerous protozoa in the intestine, absorption of tetracycline hydrochloride in infected mice was not changed to a statistically significant extent, as blood drug levels increased only slightly: behavior was similarly unaffected. Reasons for the apparent lack of virulence of this strain are discussed.

Accepted for publication December 4, 1976.


* Mailing address: Via Ceradini 3, 20129 Milano, Italy.






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Copyright © 1977 by the American Society of Tropical Medicine and Hygiene.