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Proteolytic, Antigenic and Immunogenic Properties of Schistosoma mansoni Cercarial Secretion Material^*

Schistosoma mansoni cercariae secrete preacetabular gland material in association with skin penetration. The material is heterogeneous and contains proteolytic enzyme(s) which comprise a small proportion of the total protein. We have immunized mice with cercarial secretion material in several protocols designed to induce a variety of antibody responses. The cercarial secretion material is sufficiently immunogenic to induce precipitating and reaginic antibody production. The antibodies obtained were not of the necessary quantity and/or quality to afford protection from a challenge infection.

Accepted for publication October 25, 1976.

^* This work was supported by the Naval Medical Research and Development Command, Work Unit Nos. MR041.05.01.0033 and MR000.01.01.1088, and Office of Naval Research Contract N0001470C0331. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the U.S. Navy Department or the naval service at large. The experiments reported herein were conducted according to the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Animal Resources, National Research Council, DHEW Pub. No. (NIH) 74-23.

Address reprint requests to: Dr. Patricia Minard, Immunoparasitology Division, Clinical and Experimental Immunology Department, Naval Medical Research Institute, Bethesda, Maryland 20014.