HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dunnebacke, T. H. Articles by Schuster, F. L. Search for Related Content PubMed PubMed Citation Articles by Dunnebacke, T. H. Articles by Schuster, F. L.

The Nature of a Cytopathogenic Material Present in Amebae of the genus Naegleria^*

T. H. Dunnebacke AND F. L. Schuster

The Naegleria ameba cytopathogenic material (NACM) obtained from freeliving and/or pathogenic amebae has been partially isolated and characterized. The evidence indicates that the material is a protein or has a protein component, and is in the estimated molecular weight range of 50,000 daltons. The partially isolated NACM, like its counterpart in the amebic lysates, is capable of sustaining itself in tissue cultures at a temperature which otherwise would inactivate it, and in serial passages through multiple dilutions. No distinctions between the NACMs from amebae of different Naegleria species or strains have been found in the biological response to the various treatments studied.

Accepted for publication October 30, 1976.

^* Supported by Public Health Service grants AI 10845, AI 13345, and AI 12058.

Present address: Viral and Rickettsial Disease Laboratory, California State Department of Health, 2151 Berkeley Way, Berkeley, California 94704.