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Effect of Length of Treatment with Bayer 2502 on Isolation of Trypanosoma cruzi and Resistance to Challenge in the Mouse^*

The effect of length of treatment of Trypanosoma cruzi with Bayer 2502 (Bay 2502, Lampit, Nifurtimox) on resistance to challenge and parasite isolation was studied in two experiments. In each, 200 mice were divided into groups of 20, infected with T. cruzi, and then treated with Bay 2502 for 1 to 8 consecutive weeks. Sixteen weeks after exposure, 10 mice from each experimental group were challenged with 150,000 trypomastigotes. The remainder were maintained for 8 more weeks and killed for isolation of parasites. Mice treated with Bay 2502 for up to 8 consecutive weeks were uniformly resistant to challenge, and parasites could not be isolated from groups treated for over 6 weeks. Results suggest that prolonged treatment with Bay 2502 eliminates T. cruzi from infected hosts and that resistance to challenge is not dependent on the presence of the organisms in mice.

Accepted for publication November 20, 1976.

^* Scientific Paper No. 4677, College of Agriculture Research Center, Washington State University, Pullman, Washington 99163. Project No. 0114.

These studies were supported in part by U.S.P.H.S. Grant GM00414 and General Research Support Grant RR05465.