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Oral Transmission of Brugia Pahangi to Dogs^*

Walter Bosworth AND Eli Chernin

Oral transmission of Brugia pahangi, already demonstrated in jirds, has now been accomplished in dogs. Beagle puppies, four anesthetized and two unanesthetized, were exposed to B. pahangi by instilling third-stage larvae (L-3s) into the mouth. Infections matured in all the dogs, and adult worms were recovered mainly from the mandibular, retropharyngeal, and axillary lymphatics. Worms were relatively numerous and peripheral microfilaremia developed in the dogs exposed under anesthetic, while worms were infrequent and microfilariae were found only intracardially in the dogs exposed without anesthetic. It appears that in orally exposed dogs, as in jirds studied earlier, the successful L-3s probably penetrated mucosa in or near the mouth.

Accepted for publication February 21, 1976.

^* Supported in part by a Research Career Award (to E. C.) from NIAID, U. S. Public Health Service, and by Contract DAMD 17-74-C-4038 from the U. S. Army Medical Research and Development Command.

Please address reprint requests to Eli Chernin.

Present address: Department of Microbiology, University of Texas Medical Branch, Galveston, Texas 77550.