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Infective Larvae of Brugia: Escape from Mosquitoes into Water and Subsequent Oral Infectivity in Jirds^*

Walter Bosworth, James J. Sullivan AND Eli Chernin

Published work showed that third-stage larvae (L-3s) escape into water from dead or dying, Brugia pahangi-infected, Aedes aegypti. The present study revealed the same escape phenomenon among B. pahangi-infected Armigeres subalbatus, Anopheles quadrimaculatus, and Aedes togoi, and among Brugia malayi-infected Ae. aegypti and Ae. togoi. L-3s maintained in water or in Lum's solution for 3 hours retained infectivity when tested in orally or subcutaneously exposed jirds; furthermore, L-3s recovered from mosquitoes dead for 24 to 48 hours were also infective by either portal of entry in jirds. Since L-3s may escape and remain infective in the field, it is conceivable that natural filarial infections might thus be acquired orally by definitive hosts.

Accepted for publication February 21, 1976.

^* Supported in part by Training Grant AI-0046 and by a Research Career Award (to E.C.) from NIAID, U.S. Public Health Service, and by Contract DAMD 17-74-C-4038 from the U.S. Army Medical Research and Development Command.

Please address reprint requests to Eli Chernin.

Present address: Department of Microbiology, University of Texas Medical Branch, Galveston, Texas 77550.

Present address: Institute for Medical Research, University of California ICMR, Kuala Lumpur 02-14, Malaysia.