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Anti-liver antibody has been demonstrated in the sera of Schistosoma japonicum-infected rabbits. By the 8th week after exposure to cercariae, perceptible levels of autoantibody were present and appeared to be directed predominantly against determinants located in the cell membrane of the hepatocyte.
Accepted for publication February 7, 1976.
* This study was supported in part by NIAID Grant AI 00884 and the U.S.-Japan Cooperative Medical Science Program administered by the National Institutes of Health under Grant AI 07724.
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