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Am. J. Trop. Med. Hyg., 25(3), 1976, pp. 395-400
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene

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Screening Large Numbers of Compounds in a Model Based on Mortality of Trypanosoma Rhodesiense Infected Mice*

Leo Rane{dagger}, Dora S. Rane AND Kenneth E. Kinnamon{ddagger}
University of Miami School of Medicine, Medical Research Annex, 5750 N.W. 32nd Avenue, Miami, Florida 33142, and Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D. C. 20012

A test system has been developed to evaluate the trypanosomicidal activity of large numbers of candidate drugs. Based on mortality of mice with blood induced Trypanosoma rhodesiense infections, it serves as a primary screen or as a secondary and confirmatory test for active compounds. Over 5,500 selected compounds have been tested; more than 6% were active.

Accepted for publication January 3, 1976.


* This study was supported by the U.S. Army Medical Research and Development Command, Department of the Army, under Contract No. DADA 17-72-C-2142.

In conducting the research described in this report, the investigators adhered to the ‘Guide for Laboratory Animal Facilities and Care,’ as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences-National Research Council.


{dagger} This test system was developed by Dr. Leo Rane (before his sudden death on 21 June 1973). It is the last of several that he developed. Dr. Rane made the world a better place to live in for his fellowman. In recognition of this the words engraved upon the plaque that was unveiled at the dedication of the Leo Rane Laboratory say it very well—"In his test systems he attained an unprecedented level of precision and successfully demonstrated the scientific value and potential of basic chemotherapy research." The continuation and close supervision of testing reported in this paper have been accomplished by Mrs. Leo Rane. The final compilation of information along with the writing presented herein were accomplished by Lieutenant Colonel Kenneth E. Kinnamon, Walter Reed Army Institute of Research, with the aid of Mrs. Rane.


{ddagger} Present address: Uniformed Services University of the Health Sciences, 6917 Arlington Road, Bethesda, Maryland 20014.






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Copyright © 1976 by the American Society of Tropical Medicine and Hygiene.