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Am. J. Trop. Med. Hyg., 25(2), 1976, pp. 326-335
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene

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Variation among Geographic Strains of Aedes Albopictus in Susceptibility to Infection with Chikungunya Virus*

Robert B. Tesh, Duane J. Gubler AND Leon Rosen
Pacific Research Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Honolulu, Hawaii 96806, and Department of Tropical Medicine and Medical Microbiology, School of Medicine, University of Hawaii, Honolulu, Hawaii 96816

Two types of variation were observed when the susceptibility of 16 different geographic strains of Aedes albopictus to oral infection with chikungunya (CHIK) virus was studied. One was differential susceptibility to infection with the virus. The other was variation in the quantity of virus present in infected mosquitoes after a standard incubation period. Mean virus titers of infected mosquitoes of different geographic strains varied almost 1,000-fold. Attempts to develop increasingly resistant or susceptible mosquito lines through genetic selection were unsuccessful. Infection rates did not change significantly despite 3 to 6 generations of selective inbreeding. In contrast, crosses between strains of high and low CHIK susceptibility yielded hybrid mosquitoes with infection rates and mean virus titers intermediate between those of the parent colonies. These data suggest that at least one factor controlling the susceptibility of A. albopictus to CHIK infection is genetic. Two lines of A. albopictus with a marked difference in susceptibility to oral infection with dengue viruses were equally susceptible to oral infection with chikungunya virus.

Accepted for publication July 26, 1975.


* This work was carried out in the laboratories of the Pacific Research Section, NIAID, and was supported in part by grant no. R22-A1-11338 from the National Institutes of Health.




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Copyright © 1976 by the American Society of Tropical Medicine and Hygiene.