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Am. J. Trop. Med. Hyg., 25(2), 1976, pp. 250-256
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene

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Clinical and Laboratory changes Consequent to Diethylcarbamazine in Patients with Onchocerciasis*

Louis E. Fazen{dagger}, Robert I. Anderson, Lynn Eckhert Fazen{dagger} AND Horacio Figueroa Marroquin
Department of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, and Onchocerciasis Section, Division of Epidemiology, General Directorate of Health Services, Guatemala City, Guatemala

This controlled study assesses the effect of a single oral dose of diethylcarbamazine (DEC) in a Guatemalan population with light infections of Onchocerca volvulus. From 8 to 24 hours after DEC, microfilariae were found with increased frequency in the urine, blood, and sputum, while the number of microfilariae per mm2 of skin decreased. The onset of signs and symptoms of reaction coincided with the appearance of microfilariae in the body fluids. Motile microfilariae were noted in the anterior chamber of the eye after the administration of diethylcarbamazine. Medication with corticosteroids appeared to reduce the symptoms of reaction without changing the laboratory results.

Accepted for publication August 2, 1975.


* This study was funded in part by grants from the World Health Organization and the Robert Wood Johnson Foundation.


{dagger} Present address: University of Massachusetts Medical School, 55 Lake Avenue, Worcester, Massachusetts 01605.






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Copyright © 1976 by the American Society of Tropical Medicine and Hygiene.