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Am. J. Trop. Med. Hyg., 25(1), 1976, pp. 26-33
Copyright © 1976 by The American Society of Tropical Medicine and Hygiene

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Evaluating New Antimalarial Drugs against Trophozoite Induced Plasmodium Cynomolgi Malaria in Rhesus Monkeys*

David E. Davidson, Jr.{dagger}, Dennis O. Johnsen{ddagger}, Prayot Tanticharoenyos{dagger}, Robert L. Hickman§ AND Kenneth E. Kinnamon||
Department of Veterinary Medicine, SEATO Medical Research Laboratory, Bandkok, Thailand, Animal Resources Division, Letterman Army Institute of Research, Presidio of San Francisco, California 94129, Animal Resources Division, U. S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701, and Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012

An antimalarial drug testing system is described which utilizes trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys. The schizonticidal activity of standard antimalarial drugs in this system is reported. The system accurately predicted anti-malarial activity in man of 8 of 9 compounds selected for clinical trials.

Accepted for publication July 9, 1975.


* This paper is a contribution from the U.S. Army research program on malaria.

In conducting the research described in this report, the investigators adhered to the Guide for the Care and Use of Laboratory Animals as promulgated by the Committee on the Revision of the Guide for Laboratory Animal Facilities and Care of the Institute for Laboratory Animal Resources, National Academy of Sciences, National Research Council.

Address reprint requests to: SEATO Medical Research Laboratory, APO San Francisco, California 96346 (Dr. Davidson).


{dagger} Department of Veterinary Medicine, SEATO Medical Research Laboratory, Bangkok.


{ddagger} Letterman Army Institute of Research.


§ U. S. Army Medical Research Institute of Infectious Diseases.


|| Division of Medicinal Chemistry, Walter Reed Army Institute of Research.






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Copyright © 1976 by the American Society of Tropical Medicine and Hygiene.