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Chloroquine Sensitivity of Plasmodium Falciparum in Ethiopia

II. Results of an In Vitro Test^*

Timothy T. Palmer, Luther B. Townley, Mesfin Yigzaw AND Joseph C. Armstrong

U.S. Naval Medical Research Unit No. 5, Addis Ababa, Ethiopia^,

Field trials were performed in two areas of Ethiopia with the Rieckmann in vitro test for chloroquine sensitivity of Plasmodium falciparum. Blood cultures from 82 test subjects showed growth of trophozoites to the schizont stage in control vials. Growth in test vials occurred in 21 cultures incubated with chloroquine at concentrations of 0.5 nanomoles or more per ml of blood. In vitro results confirm previous results obtained with an in vivo test.

Accepted for publication August 30, 1975.

^* The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

Supported by the Bureau of Medicine and Surgery Work Unit No. MF1.524.009.0031.BB61 and MF51.524.009.3016B.

LCDR, MSC, USN.

HMC, USN, U.S. Naval Hospital, Millington, Tennessee 38054.

Mailing address: U.S. Naval Medical Research Unit No. 5, APO New York 09319.