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Am. J. Trop. Med. Hyg., 24(6), 1975, pp. 955-962
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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Resistance to Infection with Schistosoma Mansoni after Immunization with Worm Extracts or Live Cercariae: Role of Cytotoxic Antibody in Mice and Guinea Pigs*

K. Darwin Murrell, David A. Dean AND E. E. Stafford
Division of Immunoparasitology, Naval Medical Research Institute, Bethesda, Maryland 20014

Mice and guinea pigs were immunized with adult and cercarial extracts prepared in different ways. Most animals responded by producing moderate to high levels of cytotoxic antibody; but no correlation with resistance to infection could be detected. Initial experiments with a 3M KCl extract and with cercarial exoantigen produced partial resistance; several attempts to reproduce those results failed. Mice immunized either by live or attenuated cercariae, while developing very low levels of cytotoxic antibody, were highly resistant to challenge infection. These results are discussed in terms of a failure to induce a cooperative immune mechanism required for the action of cytotoxic antibody. It is suggested that homocytotropic antibodies may play a "gatekeeper" role by initiating a reaction that promotes the translocation of serum cytotoxic antibodies and cells into the tissue surrounding the migrating schistosomules.

Accepted for publication June 14, 1975.


* Supported by the Bureau of Medicine and Surgery Work Units No. MR041.05.01.0023A6G1 and MF-51.524.009.0053BF61.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

The animals used in this study were handled in accordance with the provisions of Public Law 89-54 as amended by Public Law 91-579, the "Animal Welfare Act of 1970" and the principles outlined in the "Guide for the Care and Use of Laboratory Animals," U. S. Department of Health, Education and Welfare Publication No. (NIH) 73.23.






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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.