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Immunological Studies in Human Schistosomiasis

I. Parasitic Antigen in Urine^*

Circulating antigens were investigated, by immunodiffusion, in sera and urines from Schistosoma mansoni infected patients. The occurrence of a thermostable parasitic urinary antigen, called M, was demonstrated in 80% of infected patients. The incidence of M component was proportional to the fecal egg count and was inversely proportional to the age of the patient. Specific anti-M precipitating antibodies were demonstrated in 41% of sera from infected patients. A statistical correlation was found between the presence of M antigen and the level of total and anti-S. mansoni IgE, and also with the 24-hour intradermal test response with S. mansoni antigen. The specificity, the origin, and the function in the immune response of the M antigen are discussed.

Accepted for publication June 21, 1975.

^* This study was supported by the Brazilian Conselho National da Pesquisa (CNPq), the Ministère Français des Affaires Etrangères, and the Centre National de la Recherche Scientifique (C.N.R.S.-ERA 422).

Address reprint requests to: Professor André Capron, Service d'Immunologie et de Biologie Parasitaire, Centre Hospitalier et Universitaire, Place de Verdun, 59000-Lille, France.