AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 24(6), 1975, pp. 901-909
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pearlman, E. J.
Right arrow Articles by Castaneda, B. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pearlman, E. J.
Right arrow Articles by Castaneda, B. F.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*DAPSONE
Medline Plus Health Information
*Malaria

Chemosuppressive Field Trials in Thailand

II. The Suppression of Plasmodium falciparum and Plasmodium vivax Parasitemias by a Diformyldapsone-Pyrimethamine Combination*

Eliot J. Pearlman, Withoon Thiemanun AND Ben F. Castaneda{dagger}
U.S. Army Medical Component, SEATO, Medical Research Laboratories, Bangkok, Thailand

In an area of Thailand where chloroquine-resistant falciparum malaria is known to exist, a chemosuppressive field trial was undertaken to test the efficacy of the preparation diformyldapsone (DFD) combined with pyrimethamine (Py) in suppressing falciparum and vivax parasitemias. Six hundred and fifty-nine Thai villagers were randomly assigned to one of five treatment groups: DFD-Py; dapsone (DDS)-Py; DFD alone; Py alone; and placebo. Five hundred and ninety-three study subjects completed the 26-week trial. The combination DFD-Py given weekly was shown to be an effective chemosuppressive against both falciparum and vivax parasitmias, causing a more than fourfold reduction in falciparum and an approximately threefold reduction in vivax parasitemias; however, this combination was not more efficacious than DDS-Py for the chemosuppression of falciparum malaria. DFD alone was only moderately effective, while there was no difference in chemosuppression between Py alone and placebo.

Accepted for publication April 21, 1975.


* This is contribution number 1341 to the Army Research Program on Malaria. For the first paper in this series see reference 6.

Address for reprint requests: USA MED COMP, SEATO, APO San Francisco 96346.


{dagger} Present address: Letterman Army Institute of Research, Presidio of San Francisco, California 94129.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.