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Comparison of two Geographic Strains of Leishmania Donovani by Resistance of Mice to Superinfection^*

Groups of mice were injected with Leishmania donovani strains Et (Burma) or 1S (Sudan) and the courses of infection were followed. Between days 20 and 30 after infection the liver parasite burdens decreased, and the numbers of amastigotes were further reduced by treatment with pentostam. Et- and 1S-recovered mice were challenged by intravenous injection of amastigotes of each strain. Although resistance to superinfection was apparent the L. donovani strains could not be differentiated by this method.

Accepted for publication March 10, 1975.

^* Supported by Research Grants AI-00092 and AI-08988, NIAID, NIH, U. S. Public Health Service, and in part by the Charles and Johanna Busch Memorial Award to the Bureau of Biological Research.