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The Development of Anti-Immunoglobulin Antibodies in Rhesus Monkeys Repeatedly Exposed to Schistosoma Japonicum^*

R. Wistar, Jr., K. D. Murrell, R. M. Lewert, M. C. Yogore, C. Cole AND W. G. Clutter

The development of anti-immunoglobulin (Ig) antibodies in rhesus monkeys repeatedly exposed to Schistosoma japonicum cercariae was studied. Anti-Ig developed in all 8 monkeys exposed 5 times to cercariae of the Formosan strain, while none of 4 monkeys exposed once to the Philippine strain developed such antibodies in the same period. All monkeys developing anti-Ig had specificities for IgA, 6 of 8 for IgM and IgG, and 7 of 8 for rabbit Ig. The persistence of anti-Ig was greatly extended in the monkeys exposed initially to the Formosan strain and then challenged with the Philippine strain. A single monkey exposed once to the Philippine strain developed anti-IgA and anti-rabbit Ig 85 weeks post-infection. No relationship between host reaction to trapped eggs and the development of anti-Ig was discerned. The results suggest that immunization protocols designed for humans be carefully examined for their potential immunopathological side effects.

Accepted for publication January 13, 1975.

^* Supported by the Bureau of Medicine and Surgery Work Unit Nos. MR041.09.01.0129B, MF51.524.014.-9008, MR 011.001.001.0003, and by the United States-Japan Cooperative Medical Science Program administered by the National Institutes of Health under A1-07724.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

The experiments reported herein were conducted according to the principles outlined in the Animal Welfare Act (PL 89-544 as amended) and followed the guidelines prescribed in DHEW Publication No. (NIH) 72-23, formerly PHS Publication No. 1024, Guide for Laboratory Animal Facilities and Care.

Clinical and Experimental Immunology Department, Naval Medical Research Institute.

Department of Microbiology, The University of Chicago.