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Am. J. Trop. Med. Hyg., 24(3), 1975, pp. 455-459
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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Specificity and Sensitivity of Skin Test Reactions to Extracts of Toxocara Canis and Ascaris Suum

I. Skin Tests Done on Infected Guinea Pigs*

Richard F. Collins{dagger} AND Michael H. Ivey
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190

The specificity and sensitivity of adult and larval somatic antigens, and perienteric fluid of Toxocara canis and Ascaris suum were investigated by using intradermal skin tests in guinea pigs. These animals were infected with low doses (0.01, 0.1 or 1.0 egg/g) of these helminths. Toxocara larval antigen (TL) induced larger reactions in Toxocara-infected animals than did the other antigens, suggesting a superior sensitivity for this antigen. In addition, Ascaris perienteric fluid (AP) provoked skin responses in these animals of a magnitude similar to those induced by TL. The reciprocal relationship, i.e., comparable reactivity of AP and TL in Ascaris-infected animals, was not apparent. In general, Ascaris larval antigen and AP elicited larger intradermal reactions than other antigens in Ascaris-infected animals. The results of this study indicated no superiority of adult antigens in differentiating Ascaris and Toxocara infections.

Accepted for publication August 31, 1974.


* This investigation was supported in part by a grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Department of Health, Education and Welfare (AI-09442).


{dagger} Present address: Infectious Disease Service, Rockford School of Medicine, 1601 Parkview Avenue, Rockford, Illinois 61111.






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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.