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Am. J. Trop. Med. Hyg., 24(2), 1975, pp. 320-325
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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Attempted Prevention of Diarrheal Disease in Apache Children with a Non-Absorbable Broad-Spectrum Antimicrobial*

Norbert Hirschhorn, William E. Woodward, Lois K. Evans, Grace H. Chickadonz, Robert S. Gordon, R. Bradley Sack, Mark Breutzman, Richard A. Cash AND Philip D. Zieve
Departments of Medicine, Johns Hopkins University School of Medicine and Baltimore City Hospitals, Baltimore, Maryland 21205, and the National Institute of Arthritis, Metabolism and Digestive Diseases, Bethesda, Maryland 20014

A double-blind study was conducted to test the prophylactic effect of a non-absorbable broad-spectrum antimicrobial (oral colistin sulfate) against acute diarrhea in Apache children. Children 1 to 6 months old had over twice the morbidity from diarrhea if assigned to the antimicrobial group as compared to placebo, while the toddler group (7–30 months) taking the antimicrobial had somewhat less diarrhea. Enterpathogenic E. coli were significantly more often isolated from the antimicrobial group (but only in well children). No special effect on the children's growth by the antimicrobial was discerned.

Accepted for publication August 31, 1974.


* This study was supported by NIAMDD Contract 71-2260.

Address reprint requests to: Norbert Hirschhorn, c/o Management Sciences for Health, One Broadway, Cambridge, Massachusetts 02142.






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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.