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Rodent Systems (Plasmodium berghei-Anopheles stephensi) for Screening Compounds for Potential Causal Prophylaxis^*

An in vivo screening system is described in which drugs administered to rats or mice and challenged with sporozoites are evaluated for their antimalarial properties (causal prophylaxis, suppression, therapy) by the presence or absence of exoerythrocytic forms and parasitemia. The system is composed of A/J mice, Sprague-Dawley rats, Plasmodium berghei, and Anopheles stephensi. Good correlation has been found between test results and practical application.

Accepted for publication November 1, 1974.

^* Presented at the International Congress of Parasitology in Munich, Germany, 30 August 1974.

This work has been supported by the United States Army Medical Research and Development Command under contract DADA 17 70 C 0115; it is contribution number 1284 to the Army Research Program on Malaria.