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Chemotherapy of Experimental Echinococcus Granulosus Infection

Trials in CF₁ Mice and Jirds (Meriones unguiculatus)

Mice and jirds with experimental secondary hydatidosis (Echinococcus granulosus) were treated at various post-infection periods with eight different drugs: iodinized oil of thymol, ethyl-N-dimethyl ether of thymol fumarate, chloroguanide, rifampin, pentamidine isethionate, amphotericin B, suramin, and methotrexate. In initial experiments with methotrexate, mice treated after 99 days of infection had significantly fewer infections at necropsy than did controls (33% and 100%, respectively). However, in subsequent studies at three dose levels of methotrexate in mice 10 days after infection and in mice and jirds 240 days post infection, no significant differences were found in the percentage of animals infected, cyst size, or number between treated and control animals. The other drugs tested were similarly without effect under the experimental conditions used.

Accepted for publication June 8, 1974.

^* Present address: Department of Medicine, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey, Pennsylvania 17033.