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Am. J. Trop. Med. Hyg., 24(1), 1975, pp. 74-82
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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Immune Response of Guinea Pigs to Schistosoma Mansoni

I. In Vitro Effects of Antibody and Neutrophils, Eosinophils and Macrophages on Schistosomula*

David A. Dean, Richard Wistar AND Priscilla Chen
Experimental Parasitology Division and Experimental Immunology Division, Naval Medical Research Institute, Bethesda, Maryland 20014

Schistosomula of Schistosoma mansoni were rapidly killed in vitro by IgG2 antibodies from serum of schistosome-infected guinea pigs and heat-labile factors present in normal serum. Addition of polymorphonuclear neutrophilic leukocytes greatly increased the rate and degree of killing. Eosinophils and macrophages did not increase the level of killing, though they did react with schistosomula already damaged or killed by antiserum. Neutrophils and eosinophils reacted with schistosomula only in the presence of specific antibody, while macrophages nonspecifically attacked dead schistosomula. Serum antibody levels reached a plateau at approximately 6 weeks after a single infection. Attempts to precoat schistosomula with antibody prior to exposure to complement were largely unsuccessful.

Accepted for publication May 25, 1974.


* Supported by the Bureau of Medicine and Surgery Work Units No. MR041.05.01.0023A6GI, and MF51.524.014.9008DA9K.

The opinions or assertions contained herein are the private ones of the author and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

The experiments reported herein were conducted according to the principles outlined in the Animal Welfare Act (PL 89–544 as amended) and followed the guidelines prescribed in DHEW Publication No. (NIH) 72-23, formerly PHS Publication No. 1024, "Guide for Laboratory Animal Facilities and Care."






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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.