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Am. J. Trop. Med. Hyg., 24(1), 1975, pp. 135-144
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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Antigenic Relationships among Phlebotomus Fever Group Arboviruses and Their Implications for the Epidemiology of Sandfly Fever*

Robert B. Tesh{dagger}, Pauline H. Peralta, Robert E. Shope, Byron N. Chaniotis AND Karl M. Johnson
Middle America Research Unit, Gorgas Memorial Institute of Tropical and Preventive Medicine and National Institute of Allergy and Infectious Diseases, National Institutes of Health, U. S. Public Health Service, Box 2011, Balboa Heights, Canal Zone, and Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University College of Medicine, New Haven, Connecticut 06510

The antigenic relationships of 21 known or presumed Phlebotomus fever group serotypes and of 2 ungrouped, solvent sensitive, sandfly-associated arboviruses (Pacui and Charleville) were studied by complement fixation, plaque neutralization, and hemagglutination-inhibition methods. Results of complement fixation and neutralization tests were specific, allowing clear separation of the various serotypes, while those of the hemagglutination-inhibition test showed broader crossing and lack of specificity. Pacui virus was shown to be a member of the Phlebotomus fever serogroup. Six new Phlebotomus fever group serotypes are also described, increasing the known members of the group to 22. The implications of these and other recent data about the epidemiology of sandfly fever are discussed.

Accepted for publication July 8, 1974.


* The International Reference Center for Arboviruses at Yale University is supported by the World Health Organization, the Rockefeller Foundation, the U. S. Army and Navy (Contract DADA-17-72-C-2170), and the U. S. National Institutes of Health (Grant AI-10984). This study was also supported by National Institutes of Health Contract NIAID 72-2514.


{dagger} Present address: Pacific Research Section, NIAID, P. O. Box 1680, Honolulu, Hawaii 96806.






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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.