AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 24(1), 1975, pp. 115-117
Copyright © 1975 by The American Society of Tropical Medicine and Hygiene

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The Relative Resistance of Dengue-Immune Monkeys to Yellow Fever Virus*

Max Theiler{dagger} AND C. R. Anderson
Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510

Dengue-immune rhesus monkeys were challenged with a South American and two African strains of yellow fever virus. Levels of viremia were reduced as compared with control nonimmunized monkeys. The results support the hypothesis that immunity to dengue in a human population acts as a barrier to establishment of yellow fever in that population.

Accepted for publication April 27, 1974.


* This paper was presented at the Conference on the Pathogenesis of Arboviral Infections, sponsored by the National Institutes of Health and held in Honolulu 22–24 September 1971. The study was supported by The Rockefeller Foundation and by the United States-Japan Cooperative Medical Science Program administered by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Department of Health, Education, and Welfare, under Grant No. 1-R22-AI-08215-01A1.


{dagger} Deceased.







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Copyright © 1975 by the American Society of Tropical Medicine and Hygiene.