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Characterization of Thogoto Virus Isolated from Ticks (Rhipicephalus Bursa) in Western Sicily, Italy

Two viral strains serologically related to Thogoto virus, an ungrouped tick-borne virus originally recovered in Kenya, were isolated from Rhipicephalus bursa collected from cattle and sheep in Western Sicily, Italy in July 1969. The topotype strain, SiAr 126, was not different from the prototype strain of Thogoto virus when tested by hemagglutination-inhibition and by complement-fixation test. However, a one-way difference was detected in the serum neutralization procedure. The Sicilian strain of Thogoto virus produced considerably higher viremia in adult hamsters than in suckling mice. Hemagglutinins of SiAr 126 virus were not found in infected suckling mouse brain, but high titered hemagglutinating (HA) antigens could be prepared from infected suckling mouse serum, infected adult hamster serum or from infected adult hamster liver. Vero cell cultures were also useful for the production of SiAr 126 HA antigen.

Accepted for publication March 16, 1974.

^* On leave from Gorgas Memorial Laboratory, Panama, R.P. Present address: New Jersey State Department of Health, P.O. Box 1540, Trenton, New Jersey 08625.