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Some Observations on the Pharmacology of Clofazimine (B663)^*

Chemical methods are described for the determination of clofazimine in serum, urine, and feces, and in homogenates of liver and spleen. Feeding clofazimine to mice resulted in a large accumulation of crystalline drug in the liver and spleen. When dosage with clofazimine was terminated tissue and serum concentrations fell extremely slowly, at rates over a period of 4 months equivalent to a half-life of about 70 days. The concentrations of clofazimine were also measured in the serum, urine, or feces of leprosy patients and a healthy volunteer. Clofazimine appeared to be incompletly absorbed in man. The relevance of these findings to the treatment of leprosy with clofazimine is discussed.

Accepted for publication February 16, 1974.

^* Address reprint requests to: Dr. G. A. Ellard, MRC Unit for Laboratory Studies of Tuberculosis, Royal Postgraduate Medical School, London W12 OHS, England.