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Origin of Circulating Antigen from the Schistosome Gut

An Immunofluorescent Study^*

Immunofluorescent staining of schistosome worms with specific anti-circulating schistosome antigen (CSA) rabbit immunoglobulin plus goat anti-rabbit immunoglobulin-fluorescein conjugate strongly suggests that the gut, and not the integument, is the site of production of circulating schistosome antigen. Plans for further studies of CSA and of its role in schistosomiasis are outlined.

Accepted for publication April 20, 1974.

^* This work was partially supported by Grant R-22-AI-02631 of the U.S.-Japan Cooperative Medical Science Program, administered by the Institute of Allergy and Infectious Disease, National Institutes of Health; and by Contract DADA-17-72-C-2056 of the Office of the Surgeon General.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department or the naval service at large.

The animals used in this study were handled in accordance with the provisions of Public Law 89–54 as amended by Public Law 91–579, the "Animal Welfare Act of 1970," and the principles outlined in the "Guide for the Care and Use of Laboratory Animals," U. S. Department of Health, Education, and Welfare Publication No. (NIH) 73–23.