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Serum Changes in Rabbits Experimentally Infected with Trypanosoma Gambiense^*

Total serum lipids, cholesterol, and protein bound iodine levels became strikingly altered during the course of Trypanosoma gambiense infection in rabbits. Serum lipid and cholesterol values increased progressively with time, attaining a 3- to 4-fold increase over control values nearing the terminal stage of infection. Electrophoresis of serum lipids revealed increased beta and pre-beta lipoprotein and the appearance of a chylomicron band. Serum protein bound iodine values were decreased in infected rabbits, indicating possible thyroid involvement. Despite widespread tissue necrosis, no changes in serum lactic dehydrognase activity or isozyme patterns were observed.

Accepted for publication February 23, 1974.

^* This work was supported by a General Research Grant from HEW, 5-S01-RR0-5422-12, and a grant from the Alexandrine Sinsheimer Fund.