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Experimental Louse-Borne Relapsing Fever in the Grivet Monkey, Cercopithecus Aethiops

II. Pathology^*

D. M. Judge, J. T. La Croix AND P. L. Perine

Nineteen grivet monkeys, Cercopithecus aethiops, were infected with the spirochete of louse-borne relapsing fever, Borrelia recurrentis, and killed at various intervals following inoculation: 4 during the initial spirochetemia; 4 during remission; 3 during relapse; 2 that were dying following severe relapses; and 6 during convalescence. The histologic changes of histiocytic myocarditis, multiple microabscesses replacing the nodular white pulp of the spleen, and hepatitis with foci of midzonal necrosis were similar to those seen in humans. These changes are rarely seen in other infectious diseases and suggest a specific toxic effect.

Accepted for publication February 2, 1974.

^* The opinions and assertions in this scientific report are those of the authors and do not necessarily reflect the official views of the Navy Department or of the naval service at large. The work was supported by the Bureau of Medicine and Surgery Work Unit No. MR005.20.01-1078B, and by a research contract project 3A061102B71Q from the Medical Research and Development Command, U. S. Army, Washington, D. C.

The experiments reported herein were conducted according to the principles set forth in "Guide for Laboratory Animal Facilities and Care" prepared by the Committee on the Guide for Laboratory Animal Resources, National Academy of Sciences, National Research Council.

Presented in part at the Eighth International Congresses on Tropical Medicine and Malaria, Teheran, Iran, 3 September 1968.

To whom reprint requests should be sent. Present address: Department of Pathology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.

Present address: SGE (Clinical Research Laboratory) Technical Training Center, Keesler Air Force Base, Mississippi 39534.