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Experimental Louse-Borne Relapsing Fever in the Grivet Monkey, Cercopithecus Aethiops

I. Clinical Course^*

D. M. Judge, J. T. la Croix AND P. L. Perine

Fifteen grivet monkeys, Cercopithecus aethiops, were infected with an Ethiopian strain of Borrelia recurrentis, the causative agent of louse-borne relapsing fever. An initial spirochetemia occurred in all. Inactivity, fever, and leukocytosis accompanied the infections. Eight of the monkeys experienced 1 relapse and 1 monkey had 2 relapses. The relapses tended to be less severe than the initial infections. The only deaths, however, occurred in 2 of the 3 monkeys with severe relapses. The clinical course of the experimental infection in grivet monkeys closely resembles that of natural infections in man.

Accepted for publication February 2, 1974.

^* The opinions and assertions in this scientific report are those of the authors and do not necessarily reflect the official views of the Navy Department or of the naval service at large. The work was supported by the Bureau of Medicine and Surgery Work Unit No. MR005.20.01-0178B, and by a research contract project 3A061102B71Q from the Medical Research and Development Command, U. S. Army, Washington, D. C.

The experiments reported herein were conducted according to the principles set forth in "Guide for Laboratory Animal Facilities and Care" prepared by the Committee on the Guide for Laboratory Animal Resources, National Academy of Sciences, National Research Council.

To whom reprint requests should be sent. Present address: Department of Pathology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.

Present address: SGE (Clinical Research Laboratory) Technical Training Center, Keesler Air Force Base, Mississippi 39534.