AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 23(5), 1974, pp. 924-929
Copyright © 1974 by The American Society of Tropical Medicine and Hygiene

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Heat Treatment of Mycobacterium Ulcerans Infections without Surgical Excision*

Wayne M. Meyers, Walter M. Shelly AND Daniel H. Connor
Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, Honolulu, Hawaii 96816 Department of Surgery, Institut Médical Evangélique, Kimpese via Kinshasa, Republic of Zaire, and Geographic Pathology Division, Armed Fores Institute of Pathology, Washington, D. C. 20306

Eight patients from Zaire with Mycobacterium ulcerans infections were treated by the local application of heat to maintain a temperature of approximately 40°C in the ulcerated area. All lesions healed without surgical intervention and without local recurrences during follow-up periods of up to 22 months. This study shows that local heat promotes healing of M. ulcerans lesions. We postulate that the mechanism is primarily by direct inhibition of multiplication of M. ulcerans. Other possible contributory effects are discussed.

Accepted for publication March 8, 1974.


* Supported in part by Grant No. DADA-17-70-G-9318, from the Medical Research and Development Command, U.S. Army, Washington, D.C.; American Leprosy Missions, Inc., New York, N. Y., and General Conference Mennonite Church, Newton, Kansas.

Presented at the Middlesex Hospital Medical School (London) Conference on Mycobacterium ulcerans, 5 July 1973.

Address reprint requests to: Wayne M. Meyers, M.D., Ph.D., Leprosy Atelier, Department of Pathology, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Honolulu, Hawaii 96816.




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A. M. Dhople and K. Namba
In vitro activity of sitafloxacin (DU-6859a) alone, or in combination with rifampicin, against Mycobacterium ulcerans
J. Antimicrob. Chemother., November 1, 2002; 50(5): 727 - 729.
[Abstract] [Full Text] [PDF]


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Copyright © 1974 by the American Society of Tropical Medicine and Hygiene.